Please process your return through the link provided above and create a new order with the exchange items. Outside US: We don’t offer direct exchanges for international customers. Exchanges are free of charge, but will be limited to one exchange per customer. Please be aware that you are able to exchange only sizes, but not colors or one item on completely different item. As soon as you have sent us your old item/s, we will go ahead and send out your exchange order. US: Feel free to opt for our exchange option where you can easily select your item in a new size. Please remember that we don’t issue a refund for the shipping cost of your original package or your return package. No disco, wedding, parade or party would be complete without the perfect amount of sparkle. Want to go big and bold with your party dress, then why not try a lovely maxi sequin dress or a dazzling gold sequin mini. Once we have received your return, it can take 5-10 business days for us to process it before issuing a refund. When it comes to sequin dresses for women, weve got a gorgeous selection waiting for you. We will deduct $4.90 from your refund amount whether you opt for one of our return bar locations or print a return label. Please allow 3 processing days for your refund to appear back in your account. We'll issue your refund to the original payment method, once your original items have been returned to us. Be sure to request a trackable return so we can keep track of your package.Take your package to your local post office (AusPost/DHL/Royal Mail/Canada Post/etc), purchase the return label and send it back to the address provided on the return note. Print a return note and place it inside your package.If available, please use the original packaging.
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When waves do get too high, the sophisticated flight controller lands the boat back in the water. The larger C-8 will be able to handle choppier water and 3-4 foot seas while remaining in flight. The C-7 stays around 70 cm or around 2 feet above the water and passes through most boat wakes without touching the surface. Unlike flat bottom or v-hull boats, Candela’s hydrofoil boats fly above the water and leave no wake. The hydrofoils that are responsible for the increased efficiency make for a much smoother ride. The C-8 is also 95% cheaper to operate than gas boats and more efficient than any other electric boat, resulting in lower electricity costs, too. The sealed C-POD drivetrain is nearly maintenance-free thanks to a 3,000-hour maintenance cycle (compared to around 100 hours for gas boats). The C-8 also boasts huge maintenance and operating cost advantages over typical gas- or diesel-powered boats, and even over other electric boats. It doesn’t get any cooler than this! Full article and video soon on /RhrIIckYig- Micah Toll September 14, 2021 So easy to fly, it makes me look like a pro. Just had the most amazing experience in Stockholm where let me take out one of their flying electric boats. And that was just the C-7, not even the upcoming C-8 that is expected to blow the previous boat out of the water (c’mon, I just had to do it). The Candela C-8 is fully loaded and includes many important features, such as a below deck cabin with sofa for four people (that converts into sleeping for two adults and two children), a bathroom with toilet and a freshwater shower, optional hard top for cold environments or for sun protection, premium sound system (which is apparently a unique experience in the cabin because the ride is virtually silent without motor noise or any waves on the hull), and a 15.4-inch high-resolution touchscreen for navigation and controls.Īnd there’s the fact that the boat literally flies over the surface of the water – something that I was fortunate enough to experience a few weeks ago in Stockholm and which I’ll be sharing a complete video and write-up of soon. These 28-foot luxury boats don’t grow on trees, and these aren’t your typical fishing boats or river skiffs. Keep in mind that we’re also talking about a niche industry here. Not just electric boats, but any type of power source. By year’s end, we expect to have a real impact on combustion engine boat sales in this size category.” “According to our data, the C-8 is the second or third most sold powerboat in the 28-foot category in Scandinavia. That feat is made all the more impressive when you consider that most of those gas-powered boats cost half of the €290,000 C-8.Īs Candela’s communications manager explained: The best-selling boat manufacturers in Scandinavia sell between 100 to 120 28-footers every year, putting Candela on track to outsell those manufacturers easily. To put that into perspective, consider that Scandinavia is the leading boat building region in Europe. The Scandinavian company unveiled its new C-8 boat just six weeks ago and has already sold more than 60 units. That mass production has allowed Candela to offer the C8 – which is larger and much better equipped – for the same price as the smaller C-7 already in use around the world. The C-POD was developed for the C-8 as part of a new design philosophy that shifts Candela’s hand-built assembly into mass production. It uses a pair of counterrotating propellors each powered by an individual motor completely submerged under the water. The boat makes use of a silent new thruster known as the C-POD, which was also developed by Candela. Not only is it electrically powered instead of relying on a gas-powered outboard motor, but it also flies above the water on a pair of hydrofoils. The C-8 is a 28-foot pleasure boat that has a few neat tricks up its sleeve. Now Candela’s investment is paying off as early sales figures show that the C-8 is handily outselling its gas-powered competition. When Stockholm-based boat builder Candela launched its C-8 electric hydrofoil boat last month, the company considered it to be the “Model S moment of leisure boats,” replacing its largely hand-built C-7 with a mass-produceable product that was superior in many ways. Below, we’ll walk you through how to create an invoice. Since your clients likely record invoices in accounts payable upon receipt and pay according to their in-house pay schedule, your clients may miss or ignore payments without invoices to trigger their pay processes. Neglecting to send invoices can delay your clients’ payments since, often, clients need to receive invoices to trigger their payment processes. And if you don’t send invoices for your work, you might never get that money. If anything, you might have to wait several weeks or months before the money in your company’s accounts receivable hits your business’s cash account. If you’re familiar with the basics of small business accounting, then you know that signing a new client doesn’t mean you’ll get their cash right away. This article is for business owners who want to know how to create an invoice for completed work.To create an invoice, make space for a header, provide a detailed itemized table and include footnotes at the bottom if needed.An invoice also contains contact information, payment terms and sometimes other notes.An invoice is an itemized document that lists all work completed for a client during a period along with each service’s price.Make invoices on the go so you can take care of business wherever you are. When you’re done making your invoice, simply download it in your preferred file format and instantly share it with your clients. All your previous designs, templates, and design assets will be saved on the cloud, and accessible whenever you need them. With the Adobe Express app, you can easily make invoices and share them even when you’re on the go. Make and share your invoice instantly anytime, anywhere. To make the process of generating invoices more efficient in the future, you can also make custom templates that include all your branding assets when you’re ready to bill your next client. Make your invoice standout even more with borders or backgrounds from our gorgeous collections of design assets. Upload branded assets like your logo, graphics, fonts, imagery, slogans and more. Customize your invoice with branded assets.Įlevate your invoice design by adding your branding. With the Adobe Express invoice maker, you can generate beautiful invoices from start to finish in just a few minutes. You can also include payment links to make payments easier. Insert your information, including client details, a list of goods or services, the amount to be paid, and taxes, if any. Start by browsing through thousands of professionally made templates, then pick one and personalize it. Making an invoice with Adobe Express is easy-to-use, no matter your design experience. Open Adobe Express on the web or download the mobile app to get started. Whether you’re making a invoice for business, school, or personal use, there are thousands of professionally designed templates to choose from that will fit your style and grab the attention of your audience. Using Adobe Express, you can quickly and easily make a standout invoice in no time. A quick and free invoice maker from Adobe Express. Go back anytime to duplicate or make changes to your invoices anytime and make as many as you’d like. Establish a theme for your invoices by adding your brand logo, color schemes, fonts, photos, and other assets so clients easily recognize who you are. Let Adobe Express be your go-to free invoice maker.Įxplore professionally designed templates to get you inspired or create your invoice from scratch. Till then any data on where sweaty chads path is lifesaving information. Since I'm a newish player, solo, older than 30, and with almost no online PvP FPS experience, it'll be another wipe at least till I'm pushing dorms marked room dressed as Killa. During various drop events I've had streams open and learned a few things, mostly stuff like where the high PMC traffic zones are so i can avoid them! But Tarkov does seem to be an exception due to the amount you need to know. (Optional) Access the pumping station at the Factory. Meds Provisions Keys Storage containers Maps See the quests overview page See the barter trades page Easter eggs and References: On the 1st of August 2020, the portrait of Therapist was briefly changed to an image of the Twitch streamer. Head of the Trauma Care Department of the Tarkov Central City Hospital. I'd never seen the appeal in watching someone else play vidya, especially not PAYING them for the privilege. Look for a small separate room right in the shops and that’s the place where you should be. Elvira Khabibullina, known by her alias 'Therapist', is a trader in Escape from Tarkov. People sending her $100 at a time so she'd notice them, presumably in their incel minds they're demonstrating their abilities as a provider and assume that surely after the next $100 she'll send them a message asking when she can move in as their sex slave. To access Dorm Room 206 on Customs, you must obtain the Dorm Room 206 key. Locate the water supply hidden inside room 206 of the Dorms on Customs. Perfect example is a girl called Ginger or similar I had on for the recent drops, the cringe was real. To complete the first part of Operation Aquarius, you must achieve the two objectives. Completing one will often reward you with experience points, trader reputation, money, valuable loot. Quests are the fastest way of gaining EXP. Some require you to pick stuff up for certain traders, while others require you to kill other operators or mark vehicles and specific places. Now I have an image I can summon - unsure if I should thank you for the mental pollution though. Quests, both player-given and dynamically generated, are intended to be a large part of Escape from Tarkov. Moderator decisions are final, please respect the moderator team and their actions. Make sure to follow the guidelines outlined in the Reddiquette for a more pleasant experience. Recent News Official LinksĪs well as the above rules, the Reddit Content Policy is in place as well - please familiarize yourself with this. Please make sure to follow the rules noted below in the side bar. This is an unofficial, community-run subreddit. This is a required location for the quest Broadcast - Part 1 In Jackets In Drawers Pockets and bags of Scavs At the ground floor of office building 1, which is located at the water treatment plant area in the north of. A key that opens the operating room with broadcasting equipment, located somewhere at the water treatment plant. Escape from Tarkov is a hardcore and realistic online first-person action RPG/Simulator with MMO features and a story-driven walkthrough currently in development by Battlestate Games. Operating room key (OR) is a Key in Escape from Tarkov. Sales quotes, payment receipts, past due notices, and printable invoice templates are all available to download for free. This article provides many options to choose from depending on the type of items you are billing for, your personal preferences, industry standards, and whether you require a template that provides automatic calculations. A range of formats are available, including templates for Microsoft Excel and Word, PDF, and Google Docs. You’ll find basic and more advanced templates, all of which are customizable and intuitive to use. Using invoice templates can save time while providing clients with clear communication and giving you a professional image.īelow is a list of over 50 free invoice templates in a wide variety of designs for both specific jobs and generic use. Some companies may use an electronic invoicing system, but templates are an easy option for small businesses and individuals who need a simple yet professional solution. Invoices may also include payment terms, shipping instructions, customer information, and tracking numbers for reference. Items and unit costs are typically itemized along with taxes, shipping charges, or other fees to show customers the total amount owed. Getting started with the Smartsheet APIĪn invoice is a document that shows the amount owed for goods sold or services provided.ENGAGE 2023 Smartsheet ENGAGE brings together our global customers, experts, and partners to share their experiences, ideas, and best practices.Smartsheet events Your hub for Smartsheet events, webinars, Q&As, and user groups.Partners Learn about the Smartsheet partner program and access our partner directory. This user-friendly, professionally designed template helps you create clear and concise invoices in no time. Streamline your invoicing process with our Basic Invoice Template. Easily Editable, Printable, Downloadable. Community Explore user-generated content and stay updated on our latest product features. Free Download this Basic Invoice Template Design in Excel, Google Sheets Format.Help and Learning A comprehensive knowledge base, including articles, tutorials, videos, and other resources that cover a range of topics related to using Smartsheet.
Scarlet Witch Halloween Costume - "Wandavision" Season Finale Outfit Slap a fake mustache on and you'll be ready to hit the field! 38. Ted Lasso came out as a surprisingly popular show upon its debut last year, and Season 2 was ranked one of the most highly anticipated shows of 2021!įans of Jason Sudeikis' all-American football coach can steal his look by wearing a classic button up shirt, navy V-neck sweater, and khaki pants. Ted Lasso Halloween Costume With Sweater Shirt and Khakis For the leader of Mystery Inc., go for a blue collar shirt and a simple white sweater! You get additional points for sporting his orange ascot. Pick up Daphne's iconic purple dress and pair it with pink tights and a chic red wig. Jeepers! If you're feeling a groovy couple costume this Halloween, why not go with Fred and Daphne from the beloved animated series? Classic Fred Jones & Daphne Blake "Scooby-Doo" Couples Halloween Costume Show your devotion by partying the night away in a fun pineapple dress or a comfy pineapple jumpsuit. The fruit became synonymous with the band way before "Pork Soda!" In an interview with Hollywood Life, Dave Bayley revealed there was a pineapple "in every piece of artwork for the first record." From then on, fans picked up on it and started bringing pineapples to shows, which even led to the infamous ban of the fruit at the 2017 Reading and Leeds Festivals. "Pineapple Party" Halloween Costume - Glass Animals Inspired Group Costumes Good accessories would include white opaque tights and eye-catching red pumps. There's not much work you'll need to put to the look - just secure Cassie's rainbow wig and her nurse costume. Want a twist on the boring, sexy nurse costume? A Cassie-inspired Halloween costume might be the perfect fit for you! Cassie Colorful Nurse Costume - "Promising Young Woman" Halloween Costume To celebrate this momentous crossover, channel your inner Peter Parker with a proper Spiderman costume! 34. To add fire to the fuel, it was later confirmed that the "old Spideys," Tobey Maguire and Andrew Garfield, would be reprising their roles alongside Tom Holland. In late August, Twitter went crazy after the Spider-Man: No Way Home trailer was leaked. For the finer details, consider wearing a silver necklace, chunky heeled boots, and lace arm sleeves. Grimes and Elon Musk 2018 Met Gala Halloween Couples CostumeĪre you looking for a creative couple's costume that hasn't been beaten to death? You're just in luck!Ĭash in on the unlikely couple's notoriety this Halloween by channeling Elon's 2018 Met Gala look in a white tux jacket and matching black pants!įor Grimes, go for a high-low tulle dress. To fully flesh out the look, you can wear a strapless black top and sexy white corset. Accessorize with Mary-Janes and a sweet blonde wig before jumping down the rabbit hole! 32. We promise everyone will know who you are within seconds! If you're wanting a more detailed look, add white stockings to your cart along with this adorable rabbit purse. If you want to feel adorable at your next party, pick her delightful blue dress. There's a reason why Alice is a go-to costume choice for Halloween! "Alice in Wonderland" Halloween Costume - Blue and White Dress Lil Nas's music videos helped define this year with their iconic looks and catchy songs! If you're looking for a Halloween costume that's both simple as well as recognizable, why not opt for Nas' hot pink jumpsuit?Īdd a letter board for the occasion and you'll find yourself ready for a Halloween-themed mugshot! 31. Lil Nas X Halloween Costume - "Industry Baby" Pink Jumpsuit For those willing to take the full plunge, get yourself a glittery newsboy cap for the full effect. Being extra is always a plus too, so shop around for bedazzled purses, funky wedge sandals, and a sexy waist chain to accessorize. You can find plenty of inspiration online, but think late 90's to early 2000s: try looking for fitted cropped tees and low-rise jeans. Whether you hated it or missed it, Y2K fashion trends are IN thanks to Gen Z! For this reason, the "Bratz" makeup look swept social media this year. The Pawns only advancing ahead arrive, in advancing row by row finally to the eighth row where according to the rule they would come to a barrier and would be immobile. If the Pawn, after f2-f4, is not immediately captured by g4 "in passing," it stays unmolested on f4 and has thereafter to contend only with the hostile Pawns of the f and e files. This species of capture is named "capture in passing" or, with the French expression capture "en passant". If, for instance, in the above position White moves f2-f4 Black may answer g4 captures f3, thus executing his original intention of capturing the Pawn on f3. And finally justice was victorious: the Pawn standing on guard was acceded the right of capture, just as if the Pawn trying to slip through had advanced one step only but the Pawn on guard cannot defer this movement but must execute it without loss of time as an immediate reply to the attempted advance. It could not be the meaning of the innovation to make the advancing Pawn immune. Naturally, the Pawn g4 on guard felt deceived, when the hostile Pawn crept through the advance posts. If f2 advances to f3, g4 can capture it thus it had been for many centuries after the introduction of the new rule, Pawn f2 could evade Pawn g4 by advancing at once to f4 and could then molest Black unpunished. To illustrate this point, look at the two Pawns f2 and g4. Its object was to accelerate the pace of the Chess events and to add to their variety, but sometimes it betrayed the obvious rights of the opponent. For instance, Pawn a2 may advance to a3 or to a4 in one move. This rule made the game more lively, and therefore the Chess world accepted it over time. The Pawn c3 has only one possible move: to advance to c4.Ībout four centuries ago, the rule was introduced that Pawns in their initial position and which are not blocked may advance one or two steps according to the plan of the player. The Pawn d4 has two possible moves: to advance to d5 or to capture e5. The position shows nine Pawns standing on the squares where they stood at the start of the game: a2, b2 e2, f2, h2, a7, b7, c7, f7 they have not moved yet the other seven Pawns have advanced during the progress of the game. Pawn g3 is blocked by g4 because the Pawn does not capture straight ahead but diagonally. The above position shows three immobile Pawns, "blocked" Pawns: g3, g4, and f7. We shall now explain the chess rules in detail and at length in order to illuminate the various logical consequences that come in to play. The rules listed above are not complete, and are too brief, but they give a vivid impression of the Chess struggle. "Checkmate" occurs when a player cannot save his King from capture. Its life is sacred the player must defend it, it perishes only when no possible resource can save it from capture. The King or the Knight, whenever they have the right to move to the square held by a hostile man, the Pawn, however, but not with a diagonal move forward to a neighboring square.Īll pieces are subject to capture except the King. The Rook, Bishop or Queen, however, can "capture" the obstruction, provided it is a hostile piece, by putting the moving piece on the square occupied by the obstruction and removing the latter into the box.Īlso, the other pieces, King, Knight and Pawn, may capture hostile men. If e3 is occupied, f4, g5, and h6 are obstructed and the Bishop may not be moved there. Thus, a Bishop on c1 may go to any square in the diagonal c1, d2, e3, f4, g5, h6 unless one of these squares is occupied Beginners: Chess Computers to Help You Learn. If you’ve seen the Disney movie Moana, you may recognize the term “Maui.” However, it’s on this dormant volcano Haleakala, or “house of the sun,” that legends go that the demigod Maui lassoed the sun from on top of the volcano’s summit to slow the sun’s descent. The lush rainforests, scenic coastline, and inspiring views make for an unforgettable adventure. Teeming with ancient and modern local culture, this Hawaiian attraction empowers a bond between people and nature. Home to the dormant volcano Haleakalā and the endangered Hawaiian geese, Haleakala National Park, boasts awe-inspiring views of the nearby mountains. Read Next: If you’re island hopping be sure to check out our post on all the best things to do in Honolulu! 2) Catch The Spectacular Sunrise At Haleakala National Park Address: 192 Maalaea Rd, Wailuku, HI 96793.Listen to Hawaiian green sea turtles appear above water for a much-needed breath at the Turtle Lagoon and observe otherworldly jellyfish drift about at the magnificent Maui Ocean Center. The center’s dedication is personified through its educational programs and exhibits designed to inspire and educate its visitors about the local culture and sea.Īt this stunning aquarium, guests can revel in one of the world’s largest collections of live Pacific corals. Step over to the largest living tropical reef aquarium in the Western Hemisphere at the Maui Ocean Center.Įstablished in 1998, the center has mastered unparalleled exhibits and in-person encounters with marine life, some of which only exist in Hawaii. You may also be interested in our guide to planning a full Maui itinerary! 1) Visit The Largest Living Tropical Reef Aquarium At The Maui Ocean Center Get ready to experience the top things to do in Maui! Maui is full of adventure! From top attractions like the largest living tropical reef aquarium at the Maui Ocean Center and touring the Ali’i Kula Lavender Farm rich with lavender scents and scenic views. 21) Golf A Few Rounds At King Kamehameha Golf Club.20) Simmer Down In The Sun’s Rays At Kaanapali Beach.16) Eat Fresh Hawaiian Seafood At The Paia Fish Market.15) Dip Into The Waters At Lahaina Harbor.14) Witness The Beauty Of Iao Valley State Park.13) Encompass Your Senses At The Ali’i Kula Lavender Farm.12) Go On An Adventure To See The Haleakala Crater.11) Spot A Green Sea Turtle At Ho’okipa Beach Park.8) Spend The Evening Savoring The Old Lahaina Luau’s Ohana Treatment.6) Laze On The Black Sand Beach, Honokalani.5) Bask In The Ancient West Maui Mountains.4) Snorkel The Stunning Waters Of Honolua Bay Marine Reserve.3) Join An Ecotour At The Pacific Whale Foundation.2) Catch The Spectacular Sunrise At Haleakala National Park.1) Visit The Largest Living Tropical Reef Aquarium At The Maui Ocean Center.No more scouring the internet trying to figure out what to do in Maui! Instead, we’ve created this list of the top 21 things to do during your time in Maui for only the most exceptional vacation! Visitors can also explore more waterfalls and hiking trails in Haleakala National Park, one of East Maui’s most popular attractions. On land, travelers come to Maui to hike to the summit of Haleakala Crater for its world-renowned sunset and sunrise views. Surfers, windsurfers, sailors, swimmers, and snorkelers travel worldwide to explore Maui’s exceptionally clear waters. You can also go hiking and cliff jumping, and exploring on some of the island’s secret, undeveloped beaches. Also, keep an eye out for sea turtles and Hawaiian spinner dolphins. If you like staying above the water, join a boat tour to observe the migrating humpback whales making their journey through Maui’s waters. The crystal blue waters make for a breathtaking snorkeling experience of the vibrant, colorful underwater life. Voted “Best Island In The U.S.” for more than twenty years, Maui has a lot to offer for locals and tourists alike. Adored for its renowned beaches, notorious sunsets and sunrises, sacred history and culture, and whale-watching opportunities, Maui is a top-notch travel destination. Termed “The Valley Isle,” Maui is the second largest of the Hawaiian Islands. Wondering what activities and attractions you can’t miss in Maui? Our guide to the best things to do in Maui is just what you need! Simply log in and navigate to the exam in canvas, as you would with a regular browser. Here Log in with your Eagle Email and Password. It will bring you to FGCU Canvas Login page Similar to Below: Now that you have located a “ LockDown Browser” icon on your device double-click it to Launch the Application.īelow is the loading Screen that will appear: Press on the “Start Menu” (Bottom Left of Screen)Ī search box should appear and "LockDown Browser" should be seen as Best match Step 3 - Launch the Application on their desktop as an icon shown belowġ. Go to ' where 'xxxxxxxxx' is your school's unique 9-digit Institution ID. Once LockDown Browser has been installed, locate the “ LockDown Browser” icon: Log in as a local administrator with full rights (In System Preferences-Users & Groups, the user account must have 'Allow user to administer this computer' enabled.) 2. Lockdown browser will then install onto your computer, and p ress finish Read over the terms of service, accept, and c lick next. The download will appear in your download browser’s download manager, located in the bottom left corner of your web browser. Once the download is completed, click LockDownBrowser-2-0-x-xx.exe to begin the LockDown browser installer setup. Navigate to the appropriate quiz, and then select Take the Quiz. If prompted, log in with your IU username and passphrase. It should redirect automatically to the IU Canvas home page. When installation is complete, launch LockDown Browser. Installation Process: Step 1 - Download the LockDown Browser InstallerĬlick on the Install Now option shown below Download and install LockDown Browser from the Respondus Download LockDown Browser page. The primary application for LockDown Browser is proctored testing in campus computer labs, but it can also be used for online “take-home” tests.įree Space : 75 MB permanent space on the hard drive When instructors specify that a quiz must be taken using the LockDown Browser, students are unable to print, copy, visit other websites, access other applications, or close a quiz until it is submitted for grading. Respondus LockDown Browser is a custom browser that restricts students to just the Canvas testing environment. Turn off all mobile devices, phones, etc.This article contains information for downloading, installing, and configuring Respondus Lockdown browser on Microsoft Windows. Respondus LockDown Browser - Student Instructions If you encounter any issues with Respondus,: Make sure LockDown Browser is available to students in the course navigation menu (Links to an external site.Before starting the test, know how much time is available for it, and that you’ve allotted sufficient time to complete it.Provide students the link below to download and install the Respondus LockDown Browser for their computers. Select a location where you won’t be interrupted Make sure a test has been published in Canvas.(You won’t be able to access the exam with a standard web browser.) For additional details on using LockDown Browser, review this Student Quick Start Guide (PDF).įinally, when taking an online exam, follow these guidelines: To take an online test, start LockDown Browser and navigate to the exam. Then download and install LockDown Browser from this link: (Note: Respondus runs on Windows, so you must be on a Windows machine to download.) Install Respondus. Important Instructions: There are 5 steps to downloading and installing Respondus 4.0. Watch this short video to get a basic understanding of LockDown Browser and the optional webcam feature (which may be required for some exams). Contact your instructor to obtain the correct download link for LockDown Browser. This course requires the use of LockDown Browser for online exams. Yarosh pulled it off in cultured dishes of UV-irradiated human cells first. In the three decades since, researchers have repeatedly demonstrated that liposomes can transport DNA repair enzymes into skin cells. Along the way, he founded a company to produce it all at scale: Applied Genetics Incorporated. Then he found a way to package it and other DNA-repair enzymes inside tiny spherical pockets of phospholipids called liposomes. In the 1980s he came up with a way to purify T4N5 that was faster, cheaper, and simpler than the techniques developed by Friedberg and his contemporaries. One of the first people to recognize this opportunity was a molecular biologist named Daniel B. The founder of Revlon famously characterized cosmetics as hope in a jar-but why would anyone settle for hope when they could actively rebuild their DNA? The idea was tantalizing, and potentially very lucrative. Once they’d been isolated, some scientists began to wonder whether these enzymes could survive in topical treatments and delivered into human skin cells. (Friedberg, the DNA-repair expert, developed a technique for doing just that in the early ‘70s.) Photolyases were derived from sources like plankton and algae. Neither do we produce the DNA repair enzyme T4 Endonuclease V, aka “T4N5”-an imposingly-named cousin of UV endonuclease that scientists first extracted from parasitized E. Humans don’t make UV endonuclease, either researchers found it in a bacterium called Micrococcus luteus. (Instead, we get by with a genetic patch-up called nucleotide excision repair, which is not only less efficient, but, let’s be honest, a lot less cool-sounding than photoreactivation.) Almost all organisms on Earth do, from animals and plants to bacteria and fungi, but at some point in their history, placental mammals like us stopped producing enzymes that heal DNA with light. Nicely done, evolution!īut evolution giveth, and evolution taketh away humans, it turns out, don’t produce photolyases. As in: They can repair DNA damage caused by sunlight … when they're exposed to sunlight. I say again: Photolyases are powered by light. Take photolyases: They’re activated by light from visible wavelengths through a process called photoreactivation. So I would have to see data to be convinced of that."ĭecades of research have shown these molecules and several of their cousins to be legitimately weird and wonderful enzymes. "And rubbing them into the skin, which is a multi-layered organ, doesn't necessarily ensure they're getting into cells. "And even if they were, enzymes are fragile," he said. But when I called him, he told me he'd never heard of any of those enzymes being applied via lotions or sunscreens. So was biologist Errol Friedberg, professor emeritus at the University of Texas Southwestern Medical Center and an expert on DNA damage and gene-repairing enzymes. To protect your genetic code from the structural harm that can lead to skin cancer is one thing-to actively correct that harm is another challenge entirely. So I was surprised, on a recent trip to Florida, to learn something new about sunscreen: Recently, several products have become available that claim to repair DNA damage inflicted by UVB rays. "Well, actually, SPF 30 lotions block about 97 percent of UVB rays-4 percent more than SPF 15 and just 2 percent less than SPF 50” is the kind of #sunscreenfact I've been rattling off, insufferably, since the age of 7. I am also a compulsive sunscreensplainer. From viral cleansers and exfoliants that cost under $15 to luxury dupes recommended by the app’s “skinfluencers,” here are the best popular skincare picks to that actually get results.Having grown up in Tucson, Arizona, one of the sunniest cities in the world, I consider myself well-versed in the carcinogenic threat of UV exposure, the skin-sparing sanctity of shade, and the redeeming qualities of the sartorial atrocity that is the broad-brimmed hat. That being said, it’s important to examine each buzzy new product and trend critically (see: this winter’s drama surrounding Purito sunscreen, a former social media darling that faced a backlash over incorrect SPF labeling). Drugstore brands and direct-to-consumer newcomers alike have seen a surge in popularity because of a handful of posts or a particularly glowing testimonial. Joyce Park are also bringing their clinical knowledge to the platform, answering questions like “Should I wear sunscreen indoors?” and debunking popular skincare myths. Dombrowski and more sharing their knowledge in informative, witty ways while making a previously opaque industry slightly more accessible for everyone. The app has become one of the biggest new beauty spaces on the internet and an incubator for a new kind of influencer, with accounts like Skincare by Hyram, What’s on Vi’s Face, J.C. If you’ve spent any amount of time scrolling through Tiktok, you’ve probably ended up seeing at least a few #skincare posts. |
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